The Missouri Opioid State Targeted Response (Opioid STR) project will expand access to integrated prevention, treatment, and recovery support services for individuals with opioid use disorder (OUD) throughout the state. Primary focus will be on rigorous, multidisciplinary provider training and education on evidence-based treatment services to uninsured individuals with OUD presenting for care within state-funded programs. Primary prevention activities will center around increased awareness and decreased availability of opioids, led by local agencies in high risk areas. Prevention of overdose deaths will be accomplished through training clinical providers and at-risk individuals on Overdose Education and Naloxone Distribution practices, and providing telemedicine didactic and consultation services to primary care providers treating chronic pain. Recovery support services will be provided in the form of Recovery Community Centers, recovery housing, and recovery management checkups, all delivered with a focus on peer engagement. The State of Missouri Department of Mental Health (DMH) is leading the project, with administration, implementation, and evaluation activities provided by the Missouri Institute of Mental Health (MIMH) – University of Missouri, St. Louis, as well as healthcare agencies, additional academic institutions, and content experts throughout the state.