The National Council on Alcoholism and Drug Abuse (NCADA) and Community Partnership of the Ozarks (CPO) are Prevention Resource Centers (PRCs) in two of the highest-need regions of Missouri (based on rates of OUD and overdose death). These PRCs will implement GenerationRx, a program focused on medication safety, declining invitations to use drugs, provision of drug-free activities, and adaptive coping skills. The curriculum and all accompanying materials are publically available online through a partnership between the College of Pharmacy at The Ohio State University and the Cardinal Health Foundation. Both NCADA and CPO will target the teen demographic given the high rates of opioid analgesic misuse in this age group. The GenerationRx modules provide basic education as well as action steps that people can use to address prescription drug misuse in their communities. The program has been promoted by SAMHSA for prevention and early intervention.